These findings are consistent with other’s reports that increased accumulation of cholesterol in lysosomes and subsequent lysosome dysfunction has been linked to the development of neurofibrillary tangles in brains of patients with Niemann-Pick type C disease (Sawamura et al., 2001; Bu et al., 2002; Distl et al., 2003; Vance, 2006; Bi and Liao, 2007; Liao et al., 2007) and our reports that endolysosome dysfunction as induced by high levels of LDL cholesterol contributes to the development of tau-pathology in neurons (Chen et al., 2010; Hui et al., 2012). Here, MAPT is linked to Niemann-Pick disease type C.