MAPT and Alzheimer disease: Multiple proteins that tend to aggregate including phosphorylated tau (Alonso et al., 1996; Alonso Adel et al., 2013; Wang et al., 2013), Aβ (Braak and Del Tredici, 2004; LaFerla et al., 2007), and ubiquitin (Dil Kuazi et al., 2003) are increasingly accumulated in neurons of individuals living with AD.