DYRK1A and Dravet syndrome: Interestingly, overexpression of DYRK1A and some direct targets, such as APP and MAPT, contributes to the early onset of neurofibrillary degeneration, β-amyloidosis, neuronal loss and dementia in DS (Rovelet-Lecrux et al., 2006, 2010; Salehi et al., 2006; Liu et al., 2008; Wegiel et al., 2011; Rovelet-Lecrux and Campion, 2012; Park and Chung, 2013).