DYRK1A and microcephaly: Several reports showed heterozygous mutations in DYRK1A in patients with multiple phenotypes, including developmental delays or intellectual disability with autism spectrum disorder, microcephaly, epileptic seizures, facial dysmorphisms and cardiac defects (Courcet et al., 2012; O’Roak et al., 2012; Bronicki et al., 2015; Ruaud et al., 2015; Van Bon et al., 2015) defining a new syndromic condition (Courcet et al., 2012; Bronicki et al., 2015; Van Bon et al., 2015).