Mainly, mouse models overexpressing Dyrk1a or trisomic for genomic segments, homologous to Hsa21 and encompassing Dyrk1a, showed that Dyrk1a overdosage was sufficient to impair cognition with defects similar to DS people (For review see Ahn et al., 2006; Dierssen and Martinez de Lagran, 2006; Dierssen et al., 2009; Guedj et al., 2012; Herault et al., 2012). Here, DYRK1A is linked to Dravet syndrome.