In rodent menopause models, ERβ agonists decrease anxiety (Walf and Frye, 2005; Hughes et al., 2008) and depression (Clark et al., 2012; Suzuki et al., 2013), improve memory (Jacome et al., 2010; Kiss et al., 2012), and modulate fear extinction (Chang et al., 2009; Zeidan et al., 2011). This evidence concerns the gene ESR2 and Anxiety.