ACHE and Alzheimer disease: Multi-target inhibitors of acetylcholine esterase and MAO (AChE/BuChE/MAO-A/MAO-B) were effective drug candidates for therapy of neurodegenerative Alzheimer's (AD) and Parkinson's diseases (PD) (Pérez et al., 1999; Marco-Contelles et al., 2006, 2009; Bolea et al., 2011; León et al., 2013; Bautista-Aguilera et al., 2014a,c; Nikolic et al., 2015b).