FCMR and age-related macular degeneration: In samples that underwent QPCR, we found an association between upregulation of TMEM176B and the presence of a risk allele of C3 in controls (P = 0.03), as well as upregulation of FAIM3 and the risk allele of C3 in all AMD patients, both atrophic and neovascular (P = 0.02).