Interesting examples are the translation initiation factors and the ribosomal proteins that are co-amplified with Myc in both mouse and human Myc-induced tumours (Supplementary Data 9), which may collectively underlie the recurrence of 8q amplifications in human MYC-induced tumorigenesis; and PDZ binding kinase (Pbk), a gene previously shown to interact with p53 and modulate the expression of its transcriptional targets41, which is intriguingly deleted in both mouse and human p53-mutant tumours (Supplementary Data 9). Here, TP53 is linked to neoplasm.