CDH5 and B-cell chronic lymphocytic leukemia: Besides we show that soluble ephrinA4 could promote a transcellular TEM route of CLL cells, as concluded from the VE-cadherin and caveolin-1 stainings of TEM assays, rather than through inducing holes in the HUVEC monolayer as observed in other endothelial studies of permeability using ephrinA1 rather than ephrinA4 [20].