To confirm a TC TEM pathway, we examined by confocal microscopy a possible association between intracellular caveolin-1 staining, which has been related with this TEM route in lymphocytes [26, 27], and the CLL cells actually inside of endothelial cells located > 1μm of interendothelial junctions. Here, CAV1 is linked to B-cell chronic lymphocytic leukemia.