CSF2 and melanoma: Of note, Talimogene laherparepvec (T-VEC), a herpes simplex virus type 1–derived oncolytic immunotherapy designed to selectively replicate within tumors and produce granulocyte macrophage colony-stimulating factor (GM-CSF) to enhance antitumor immune response, is the first approved oncolytic immunotherapy by the US Food and Drug Administration (FDA) demonstrated therapeutic benefit against melanoma [10–12].