However, in the GATA2/3 double KO mice, the AR transcriptional activity was significantly reduced as measured by the expression levels of AR target genes (Figure 6), suggesting that the phenotype of GATA2/3 double KO mice might not be the same as the typical PIN lesions observed in PTEN knockout mice [55]. This evidence concerns the gene GATA2 and prostate intraepithelial neoplasia.