The striking effects of roneparstat in sarcoma cells endowed with PDGFR activating autocrine loops [31 and our data not shown] prompted us to investigate the ability of the HS mimic to inhibit the transforming potential of the COL1A1/PDGFB chimeric protein generated by the chromosomal translocation t(17;22) in DFSP [4, 5]. This evidence concerns the gene PDGFB and sarcoma.