TP53 and neoplasm: In particular, miR-143, miR-145 and miR-215 are considered tumor suppressors, downregulated in EAC probably due to additional molecular alterations that occur during carcinogenesis, such as loss of p53 homozygosity with consequent alteration of the functionality and ability that p53 exerts on the regulation of these three miRNAs [23, 34–36].