In addition, activation of DCs induced by TLR7/8 agonists results in increased secretion of interferon (IFN)-α, interleukin (IL)-12, and tumor necrosis factor (TNF)-α, as well as upregulation of costimulatory molecules such as CD80 and CD86, increased polarization towards Th1-type responses, and enhanced tumor lysis [20–22]. This evidence concerns the gene TNF and neoplasm.