While the present findings and those by others implicate stimulation of NO generation from constitutive synthases (mainly NOS3) as the main driver of antihyperplastic and antiinflammatory effects against the TPA-induced tumor-promoting tissue changes (Figure 1) [26], stimulated generation of NO from NOS3 or exogenous sources have been also reported with three other modes of direct and indirect anticancer mechanisms. This evidence concerns the gene NOS3 and neoplasm.