VEGFA and sarcoma: Given doxorubicin (which blocks HIF-1a binding to target DNA) is one of the commonly used chemotherapies for sarcomas and pazopanib (which blocks VEGF-A receptors) is FDA-approved for sarcomas, one can readily envision a clinical trial of doxorubicin combined with VEGF-A inhibition and hypoxia-activated chemotherapy for patients with advanced sarcomas.