HIF1A and neoplasm: HIF-1α is then transported to the nucleus where it binds hypoxia response element (HRE) DNA sequences and activates the expression of at least 150 target genes, including genes eliciting changes in tumor angiogenesis (e.g. vascular endothelial growth factor A or VEGF-A) [4] and invasion (e.g. c-MET) [6].