FLT3 and acute myeloid leukemia: Of note, while cells from Patients 5 and 6, with FLT3-WT AML, showed close to maximum induction of apoptosis with DNR alone at 100 nM and 500 nM, respectively, lack of enhanced apoptosis in the presence of AZD1208 was seen at the lower DNR concentrations tested (Figure 2B).