Therefore, we inhibited the SCF complex by expressing a dominant-negative mutant of the core SCF subunit Cullin-1 (Cul1-N252) and found a strong increase of Cdh1 in the AML cell lines Kasumi-1 and HL-60, while there was no difference in the cell cycle profile (Figure 1G). Here, KITLG is linked to acute myeloid leukemia.