It has been shown that expression of Cdh1 is specifically increased during PMA-induced megakaryocyte differentiation of the bcr-abl positive myeloid leukemia cell line K562 [33], hence supporting PMA effects in non-APL AML without t(15;17), which is consistent with our data in HL-60. This evidence concerns the gene CDH1 and acute promyelocytic leukemia.