In order to study the role of APC/CCdh1 in AML, we analyzed the protein expression patterns of Cdh1 in primary human AML blasts and the role of Cdh1 knockdown (kd) on induced differentiation in two cell lines derived from different AML subtypes using our previously validated highly efficient short hairpin (sh)RNA against Cdh1 [4, 25]. Here, APC is linked to acute myeloid leukemia.