We found that only for rs2364723 there was a significant decrease in the serum HMOX1 levels in T2DM patients for the GG genotype carriers compared with participants with CG+CC genotype [0.592 (0.230–0.152), P = 0.038], suggesting that NFE2L2 polymorphism of rs2364723 may cause an increase in serum HMOX1 level in T2DM patients. This evidence concerns the gene NFE2L2 and type 2 diabetes mellitus.