OPG plasma levels are also a predictor of asymptomatic coronary artery disease in type-2 diabetic patients and OPG plasma levels are also significantly higher in patients with systemic hypertension, decreased kidney function, and type 1 diabetic patients with nephropathy and signs of cardiovascular disease (Ueland et al., 2004, Avignon et al., 2005, Ueland et al., 2005, Rasmussen et al., 2006). The gene discussed is TNFRSF11B; the disease is Nephropathy.