OPG plasma levels are also a predictor of asymptomatic coronary artery disease in type-2 diabetic patients and OPG plasma levels are also significantly higher in patients with systemic hypertension, decreased kidney function, and type 1 diabetic patients with nephropathy and signs of cardiovascular disease (Ueland et al., 2004, Avignon et al., 2005, Ueland et al., 2005, Rasmussen et al., 2006). Here, TNFRSF11B is linked to cardiovascular disorder.