For 16 of these variants, data were available from AJex; 2 variants were nominally significantly (P < .05) associated with AJ CD: the NOD2 frameshift rs2066847 (AJex P = 2.1 × 10-25) and a frameshift mutation in CSF2RB (p.S709LX22). Here, NOD2 is linked to Cowden disease.