PCNA and ataxia telangiectasia: PCNA has a central role in DNA replication, repair, and chromatin dynamics, as illustrated by a mutation in human PCNA associated with DNA repair deficiency syndrome akin to diseases like xeroderma pigmentosum, Cockayne syndrome, and ataxia telangiectasia (Baple et al., 2014, Duffy et al., 2016).