Significant two-way interactions (p < 0.001) among the biomarkers in association with AKI events were observed for the Ang-2/Ang-1 ratio and IL-17, VCAM, Ang-2, and G-CSF, and for sVCAM with TNFR-1 and Ang-2, and for Ang-2 with TNFR-1. This evidence concerns the gene CSF3 and acute kidney injury.