PEG10 and hepatocellular carcinoma: Our findings demonstrate that miR-122 normally downregulates PEG10 protein expression and this regulation is lost in HCC (Fig. 5), suggesting that the combination of downregulation of miR-122 and upregulation of PEG10 protein can be serve as early biomarkers for identifying an HCC subpopulation that is at high risk for poor outcome.