In China and Hong Kong, 39.5 and 80 % of HCC patients, respectively, have increased copy numbers of the PEG10 gene [26], while PEG10 mRNA is detected in 67, 80 and 67 % of HCC cases in China, Hong Kong, and Taiwan, respectively [19, 26]. This evidence concerns the gene PEG10 and hepatocellular carcinoma.