The expression patterns of p53 isoforms were studied in various cell lines, such as colorectal adenoma, renal cell carcinoma, mucinous ovarian cancer, serous ovarian cancer, breast cancer, cholangiocarcinoma, acute myeloid leukemia (AML), squamous cell carcinoma of the head and neck (SCCHN), and melanoma cell lines. The gene discussed is TP53; the disease is head and neck squamous cell carcinoma.