TNFSF12 and systemic sclerosis: In many previous studies, it was thought that TWEAK could play a part in the pathogenesis of autoimmune/chronic inflammatory diseases.[21,22] Some of these diseases are rheumatoid arthritis, systemic lupus erythematosus, systemic sclerosis, and multiple sclerosis.[14] We have not come across a study that examines TWEAK levels in celiac disease, which is another autoimmune/chronic inflammatory disease.