After these explanations, we can say that after gluten intake in celiac disease a T-cell-mediated immune response occurs and proinflammatory cells such as Th1 and Th17 play a role in this immune response.[20] While Th17 shows its major effect via IL-17A, Th1 could play a role through the TNF superfamily. The gene discussed is IL17A; the disease is celiac disease.