A TNF-like weak inducer of apoptosis (TWEAK), which is a cytokine from the TNF superfamily, shows its activity via the fibroblast growth factor-inducible 14 (Fn14) receptor.[9] TWEAK has two active forms as soluble and membrane bound.[10] Soluble TWEAK (sTWEAK) plays an important role in inflammation, apoptosis, and atherosclerosis.[11]. Here, TNFSF12 is linked to atherosclerosis.