Actually, several other score systems in diagnosing high-risk UGIB or adverse clinical outcomes of NVUGIB patients have already been applied in the clinic.[18] In the study by Ogasawara et al,[19] age ≥70 years, shock on admission, Hb <8.0 g/L, serum albumin <33 g/L, exposed vessels with a diameter of ≥2 mm on the bottom of ulcers, and Forrest type Ia and Ib predicted intractable endoscopic hemostasis. This evidence concerns the gene ALB and ulcer disease.