The innovative application of MS‐MLPA in this analysis of oligodendroglial tumors allowed for identification of a number of novel and interesting epigenetic alterations, including involving APC, MLH1, ATM, RARB, HIC1, BRCA1, CASP8, BRCA2, CD44, VHL, FHIT, IGSF4, CDH13, and MLH1. Here, APC is linked to oligodendroglial tumor.