Both CDKN2A and CDKN2B, tumor suppressor genes encoding p16 (INK4a) and p15 (INK4b), respectively, which are localized to 9p21 and act via the Rb and p53 pathways, have been found to be aberrant to some degree in gliomas 21, 22. This evidence concerns the gene CDKN2B and glioma.