The innovative application of MS‐MLPA in this analysis of oligodendroglial tumors allowed for identification of a number of novel and interesting epigenetic alterations, including involving APC, MLH1, ATM, RARB, HIC1, BRCA1, CASP8, BRCA2, CD44, VHL, FHIT, IGSF4, CDH13, and MLH1. The gene discussed is HIC1; the disease is oligodendroglial tumor.