Importantly, this study was the first to identify 14 methylated genes in oligodendroglial tumor patients, namely APC, MLH1, ATM, RARB, HIC1, BRCA1, CASP8, BRCA2, CD44, VHL, FHIT, IGSF4, CDH13, and MLH1. Here, MLH1 is linked to oligodendroglial tumor.