Furthermore, we also demonstrated in hepatocyte-specific Ppara-/- mice (i.e., Pparafl/flAlbCre/+) the presence of liver steatosis at P3, thereby confirming that the phenotypes observed in Ppara-/- mice is most likely due to the hepatocyte-specific effects (Figure 4— figure supplement 1I) (Montagner et al., 2016). The gene discussed is PPARA; the disease is fatty liver disease.