A similar action can be observed for the extracellular glycosaminoglycan hyaluronan, whose synthesis can be induced by TGFβ signaling; hyaluronan activates TGFβ signaling and its downstream transcriptional mediators Snail1 and Twist1, thus promoting EMT and the enrichment of tumor cells in cancer stem cell populations [25]. This evidence concerns the gene TGFB1 and cancer.