Another gene that is affected by such epigenetic regulation is the metastasis suppressor 30 kDa HIV-1 Tat-interacting protein (TIP30), whose expression is repressed by TGFβ signaling via enhanced hypermethylation of the TIP30 regulatory sequences in esophageal carcinoma cells [204]. Here, HTATIP2 is linked to carcinoma of esophagus.