While most studies have focused on the dependence of EMT on the regulatory loops between Snail1, Snail2, ZEB1, ZEB2 and Twist1, unbiased mathematical modeling of the EMT response in lung adenocarcinoma A549 cells has also revealed a similar interdependent network that includes the transcription factors HNF4α, Ets2 and JunB [155]. This evidence concerns the gene JUNB and lung adenocarcinoma.