TGFB1 and neoplasm: On the other hand, the presence of the lipid raft domain protein, flotillin-2, on the surface of nasopharyngeal cancer cells correlates with enhanced invasiveness and metastatic potential, which is attributed to enhanced TGFβ signaling causing Src tyrosine kinase activation and β-catenin mobilization to the nucleus, supporting an EMT response in this tumor cell type [90].