In pancreatic adenocarcinoma where the TGFβ pathway is intact and the cells express Smad4, TGFβ induces Snail1 and EMT; however, under the coordinate transcriptional regulation between Smads and Snail1, the epithelial transcription factor, KLF5, becomes repressed. This evidence concerns the gene SNAI1 and pancreatic adenocarcinoma.