TGFB1 and thyroid gland carcinoma: In a parallel mechanism, thyroid epithelial cells undergoing EMT in response to TGFβ induce expression of cadherin-6 (also known as K-cadherin) and this cadherin is found expressed at high levels in aggressive thyroid carcinomas, thus classifying cadherin-6 as a TGFβ-inducible mesenchymal cadherin [46].