Independent studies in breast cancer EMT have indicated that TGFβ-induced Sox4 contributes mainly to the transcriptional upregulation of mesenchymal genes, such as N-cadherin and vimentin, via direct binding of Sox4 to the promoters of these genes, however, the exact transcriptional mechanism has not been clarified yet [187]. Here, TGFB1 is linked to breast carcinoma.