Interestingly, when pancreatic tumors mutate their Smad4 gene and thus lose its expression, TGFβ signaling fails to induce Snail1 or EMT, however, it can induce Sox4 expression; the coordinate action of Sox4 and the pre-existing KLF5 promotes tumorigenesis [184]. This evidence concerns the gene SNAI1 and pancreatic neoplasm.