There is also evidence showing that infection with bovine viral diarrhea virus (BVDV), a Flaviviridae pestivirus, impairs the arsenite-mediated SG assembly; despite the fact that BVDV N-terminal protease (Npro) is able to interact with several RNA granules components, such as YB-1, IGFBP2, DDX3, ILF2 and RHA (DXH9) [175]. The gene discussed is DDX3X; the disease is infection.