In addition, given that DDX3 has been implicated in the sensing of viral RNA to modulate IFN production and SG assembly (reviewed in [180]), Thulasi Raman and colleagues showed that DDX3 interacts with NP and colocalizes in SGs upon infection with an IAV mutant lacking NS1, suggesting a novel antiviral function for DDX3 [192]. Here, DDX3X is linked to infection.