Interestingly, a correlation has been reported between AQP4 expression and the incidence of epileptic seizures in GBM patients: in particular, it was found that, even if all GBM patients enrolled expressed similar amounts of AQP4 mRNA, patients with seizures had a higher amount of AQP4 in the cell membranes, thus suggesting a post-transcriptional regulation of AQP expression [131]. Here, AQP4 is linked to glioblastoma.