AQP1 and neoplasm: In conclusion, many studies have reported the importance of AQP1 in cerebral edema, tumor growth, angiogenesis, and neoplastic invasiveness; one of the possible mechanisms involved seems to be the induction of endothelial cell migration, depending on a water influx into the cells, with consequent expansion of their protrusions (lamellipodia) [102,103,121,122].