TMPRSS11D and cancer: Acetylation of histone and non-histone proteins by GNATs controls gene expression, regulation of transcription factors, DNA replication, DNA repair, cell cycle progression, cell signaling pathways and metabolism (Table 2) [44,46,189,190], and misregulation of the histone N-acetyltransferase (HAT) activity has been linked with cancer, asthma and viral infections [9,10,189,191,192].