DNMT3A and acute myeloid leukemia: The presence of a mutated DNA methyl transferase gene DNMT3A has been associated with a worsened prognosis in CN-AML and adverse-risk AML.37 Partial tandem duplications of KMT2A (previously known as MLL), which encodes a histone methyltransferase, have also been associated with a worse prognosis in CN-AML.6, 10, 36 The prognostic impact of IDH-1/IDH-2 mutations is less well established and is likely modified by co-occurring mutations.