Among patients with t(8;21), the presence of a c-KIT mutation significantly increases the risk of relapse, and decreases OS to levels comparable to those of patient with intermediate-risk AML.6, 23, 25 Although there is some evidence that the presence of c-KIT mutations similarly lowers prognosis in patients with inv(16),26 recent studies have failed to show any prognostic impact in this subset of cases.6, 27, 28 Molecular changes have a particularly important role in refining the prognosis of patients with CN-AML, which includes nearly half of de novo AML cases. Here, KIT is linked to acute myeloid leukemia.