FLT3 and acute myeloid leukemia: Although no DLT were observed in this study, neutropenia, thrombocytopenia and anemia developed in 96, 94 and 61% of patients, as well as infections and a decreased left ventricular ejection fraction in 56 and 11% of patients, respectively.89 In a recent randomized, double-blind trial of 717 patients with previously untreated FLT3 (ITD and TKD) positive AML, Stone et al. explored the role of midostaurin in combination with a standard ‘7+3' induction regimen and high-dose cytarabine consolidation therapy.