RUNX1 and acute myeloid leukemia: Persistently elevated levels of RUNX1-RUNX1T1 transcripts after induction therapy in patients with t(8;21) AML are thus associated with an increased incidence of relapse.41, 42 Similarly among patients with intermediate-risk disease, detection of minimal residual disease by flow cytometry is an independent predictor of relapse and survival43, 44 and carries important implications for management.45