Several studies have shown a significantly worse prognosis in patients with higher mutant to wild-type allelic ratios.34, 35 TP53 mutations, which are found in only 2– 8% of cases,6, 7 occur more frequently in cases with unfavorable cytogenetic and a complex karyotype.36 However regardless of the cytogenetic profile, TP53 mutations are associated with a very poor prognosis10 and may in fact represent the single worst genetic prognostic factor.36 Mutations in DNA-related genes also carry important implications for the prognosis and treatment of AML. Here, TP53 is linked to acute myeloid leukemia.