Several small molecules of STAT3 inhibitors have been developed and are currently being investigated for the treatment of AML: in 2011, Redell et al. showed decreased STAT3 phosphorylation and induction of apoptosis in AML cell lines treated with the STAT3 inhibitor C188-9.98 More recently, the optimized compound MM-206 demonstrated a dose-dependent induction of apoptosis in AML cell lines cultured in the presence of bone marrow stromal cells. Here, STAT3 is linked to acute myeloid leukemia.