FGFR1 and small cell lung carcinoma: The FGFR1 gene is amplified in lung cancer at varying frequencies (depending on the histological subtype between 5.6% and 19% for SCLC and NSCLC SCC, respectively) and overexpression of FGFR1 was shown to be a driving oncogenic factor in subgroups across all lung cancer subtypes [23-26].