However, compared to the IKKα, IKKβ, IKKβ+IKKγ, IKKα+IKKγ, IKKα+IKKβ+IKKγ overexpression group, the interplay between TERT and TERC, TERRA and TERT, TRF2 and telomere, CST/AAF and telomere were significantly not altered when IKKα plus IKKβ or IKKγ were overexpressed in HOTAIR knocked-down liver cancer stem cells (Figure 8C). This evidence concerns the gene IKBKB and liver cancer.