Conversely, when single IKKγ was only overexpressed, the tumor weight significantly compared to the control, IKKα, IKKβ, IKKβ+IKKγ, IKKα+IKKγ, IKKα+IKKβ+IKKγ overexpression group (0.21±0.05 gram vs 0.75±0.15 gram, 0.66±0.12 gram, 0.68±0.07 gram, 0.72±0.16 gram, 0.69±0.12 gram, 0.74±0.18 gram, p<0.01, respectively), and there, however, were no significant difference among control, IKKα, IKKβ, IKKβ+IKKγ, IKKα+IKKγ, IKKα+IKKβ+IKKγ overexpression cell lines (P>0.05). The gene discussed is CHUK; the disease is neoplasm.