Furthermore, although HOTAIR depletion inhibited the xenograft tumor formation (0.65±0.15 gram vs 0.21±0.05 gram, 0.24±0.06 gram, 0.2±0.03 gram, 0.23±0.0 gram, 0.19±0.02 gram, 0.25±0.06 gram,0.26±0.05 gram, respectively, P<0.01), IKKα plus IKKβ overexpression and single IKKγ overexpression did not alter xenograft tumor formation ability in HOTAIR depleted cells groups (IKKα, IKKβ, IKKγ, IKKα+IKKβ, IKKβ+IKKγ, IKKα+IKKγ, IKKα+IKKβ+IKKγ) (P>0.05) (Figure 9D). The gene discussed is CHUK; the disease is neoplasm.