This assertion is based on several observations in IKKα plus IKKβ or IKKγ overexpressed liver cancer stem cells: (1) IKKα plus IKKβ enhanced and IKKγ inhibited the interplay among HP1α, HP1β and HP1γ that competes for the interaction among HP1α, SUZ12, HEZ2. Here, CHUK is linked to liver cancer.