This assertion is based on several observations in IKKα plus IKKβ or IKKγ overexpressed liver cancer stem cells: (1) IKKα plus IKKβ enhanced and IKKγ inhibited the interplay among HP1α, HP1β and HP1γ that competes for the interaction among HP1α, SUZ12, HEZ2. This evidence concerns the gene SUZ12 and liver cancer.