Pathological picture (HE stain) of xenograft tumor showed that tumor tissue possessed more poor-differentiation cells and less moderately or well-differentiation cells in the IKKα and IKKβ co-overexpressed group, and less poor-differentiation cells and more moderately or well-differentiation cells in single IKKγ overexpressed group than that of control, IKKα, IKKβ, IKKβ+IKKγ, IKKα+IKKγ, IKKα+IKKβ+IKKγ overexpressed groups (Figure 2D, Upper). This evidence concerns the gene IKBKB and neoplasm.