SRA1 and central nervous system cancer: Transplantation itself did not change orthotopic glioma phenotypes in mice (tumor volumes 21 days post inoculation: Sr-a1+/+ to Sr-a1+/+: 42.9 ± 14.8 mm3; Sr-a1−/− to Sr-a1−/−: 81.9 ± 27.5 mm3) (Figure 5Aa & 5Ba).