DUSP5 and Familial prostate cancer: To probe for the effect of EpMs, in combination or not with IFN, on the expression of a subset of ISGs in LNCaP cells, we measured by qRT-PCR the relative expression levels of STAT1 and IRF7 (ISGs that transduce the IFN signal [48]), and MX1 and DUSP5 (ISGs that play roles in innate immunity and also show anti-oncogenic activities in prostate cancer [49, 50]).