IFNA1 and Familial prostate cancer: In the present study we employed the abundantly researched hormone-dependent LNCaP prostate cancer cell line and two different RNA viruses, hMPV and EHDV, to explore the functional interaction between two features of prostate cancers: aberrant epigenetic regulation of gene expression [6, 17–20, 25, 26, 42] and defects in IFN signaling or expression of ISGs [16, 17, 45, 61]].