APOE and atherosclerosis: While the adenovirus-mediated gene transfer of interleukin-10 in an hyperlipidemic LDLr knock-out mouse model results in lowering of cholesterol levels and attenuation of atherogenesis, interleukin-10 deficiency in a distinct hyperlipidemic apolipoprotein E knock-out mouse model leads to an increase of LDL and atherosclerosis (Caligiuri et al., 2003; Von Der Thüsen et al., 2001).