CASP3 and hepatocellular carcinoma: In addition, previous reports have also demonstrated that the glycine- and proline-rich glycoproteins, which consists of carbohydrates (69.74 %) and proteins (30.26 %), can stimulate mitochondria-mediated apoptotic signaling (cytochrome c, caspase 3, and PARP) and inhibit the activities of NF-κB in hepatocellular carcinoma cells (Oh and Lim, 2007[36]).