For instance, hypermethylation of this gene has been observed in early stage lung adenocarcinoma, which could lead to a decrease in its expression (Shu et al. 2006), and Acinus cleavage by caspase-3 has been observed upon apoptotic stimuli (Sahara et al. 1999) but also during erythropoiesis (Zermati et al. 2001). The gene discussed is CASP3; the disease is lung adenocarcinoma.