Nevertheless, the point estimate for nitrofurantoin, as a proxy for urinary tract infections, was similar to a recent study investigating the influence of pravastatin on incident urinary tract infection among adults with persistent microalbuminuria, a condition associated with elevated Rac1 activation,50 in a randomized setting (aSR 0.85 vs HR 0.83).51 The effect against specific types of infections and the generalizability of our findings to other high‐risk patient groups deserves further investigation. Here, RAC1 is linked to infection.