RAC1 and diabetes mellitus: Statins are also known to reduce the amount of membrane‐associated or activated Rac1,13, 14, 15 a Rho GTPase involved in bacterial invasion.16, 17, 18, 19 This activity against Rac1 may explain the observation in pre‐clinical studies that statins reduce bacterial invasion.20, 21 Several studies indicate that diabetes is associated with increased Rac1 activation,22, 23 suggesting that statins should be particularly effective among patients with diabetes.