Here, we demonstrated that miR-2861 suppressed all the three members of the EGFR/AKT2/CCND1 signaling pathway by directly binding to the 3′UTR of EGFR, AKT2, and CCND1, and found that silencing anyone of EGFR or AKT2 or CCND1 could inhibit the tumor properties of cervical cancer cells, similar to that of miR-2861 overexpression. The gene discussed is EGFR; the disease is neoplasm.