We further explored the effects of a defective DNA damage response pathway (which is one of the hallmarks of cancer) on the sensitivity to liquid plasma, since ATM-CHK2 pathway is known to be required for the p53-dependent apoptosis induced by radiation4, 26 and loss of ATM-CHK2 axis potentiate glioma radiation resistance27. The gene discussed is TP53; the disease is central nervous system cancer.