In addition, plasma can target the cell membrane, possibly via lipid peroxidation40 and extracellular matrix14, and exerts its effects on DNA21, 22, 39, JNK/p3817, 23 or NFκB24 signaling pathway, and on mitochondria15, 16, 17, 18, 39 in various cancers via production of ROS/RNS as we demonstrated here. This evidence concerns the gene MAPK8 and cancer.