Using hMSC, a model cell type that is crucial in the development of glomerular fibrosis, which contributes to the pathogenesis of diabetic nephropathy [28], we found that high glucose induced the expressions of both CTGF mRNA (Figure 1A) and protein (Figure 1B), which is consistent with previous observation from human renal fibroblast cell [29]. This evidence concerns the gene CCN2 and diabetic kidney disease.