There was significant enrichment of the ‘blue’ module with 840 fragile X mental retardation protein (FMRP) target genes36 (P < 1.36 × 10−128, OR = 6.25; empirical P < 1.0 × 10−05), 246 genes impacted with de novo LOF mutations in ASD cases35, 37, 38, 39, 40 (P < 5.9 × 10−04, OR = 1.79; empirical P < 2.1 × 10−04) and 141 genes that had de novo exonic deleterious mutations in intellectual disability samples41, 42 (P < 8.0 × 10−03; OR = 1.80; empirical P < 2.3 × 10−03) from exome and whole genome sequencing (Fig. S6A–C). This evidence concerns the gene FMR1 and Intellectual disability.