APOE and Alzheimer disease: Novartis and the Banner Health Institute have begun phase II/III trials testing this novel vaccine with a BACE I inhibitor in pre-symptomatic, cognitively healthy adults, who have two copies of the ApoE4 gene, making them more at risk of developing AD, in a trial known as the Alzheimer’s Prevention Initiative APOE4 trial, expected to reach completion in 2023 (www.alzforum.org).