We now suggest a more extensive set of associations involving ATG5 and WAC, and by virtue of the role of MYC in autophagy31, CCAT1, CDCA7L, DNMT3A and CBX7. Collectively, these data invoke deregulation of DNA methylation, telomere length, differentiation and autophagy, and immunoglobulin production as determinants of MM susceptibility. Here, WAC is linked to Miyoshi myopathy.