Since global HIF-1α knockout is lethal, to further elucidate the roles of aberrantly increased HIF-1α in the pathogenesis of AAA, EC or SMC-specific conditional HIF-1α/ApoE triple genetic modified mice, such as tamoxifen-inducible Cre recombinase under target site promotor might be required42, 71. Here, HIF1A is linked to triple-A syndrome.