Furthermore, an index consisting of serum IL-34, type IV collagen 7s, and age, which was established by multiple regression analyses, was superior to IL-34, M-CSF, sCD163, macrophage inflammatory protein-3 alpha/C-C motif chemokine ligand 20 (MIP-3α/CCL20), hyaluronic acid, type IV collagen 7s, and fibrosis scores in diagnosing the liver-fibrosis stages. The gene discussed is CD163; the disease is Hepatic fibrosis.