Notch2 activation was observed in 10.0% (1 of 10) of noncancerous endoscopic mucosa, 71.4% (30 of 42) in premalignant lesions, and 97.3% (72 of 74) in gastric cancer tissues, demonstrating a correlation of Notch2 expression with both intestinal and diffuse gastric cancer formation45. Here, NOTCH2 is linked to gastric cancer.