C1QBP and cancer: Our present data also show that antibody neutralization of cell-surface gC1qR prevented ligand-induced lamellipodia formation, cell migration, cell attachment and RTK signaling in various cell lines such as A549, MDA-MB-231, MCF7, HeLa and HUVEC, suggesting that antibody neutralization of cell-surface gC1qR can be a useful treatment strategy for various cancers that overexpress gC1qR and RTKs in the plasma membrane.